Please use this identifier to cite or link to this item: https://app.uff.br/riuff/handle/1/11511
Title: Polimorfismo no gene MMP2 está associado com ausência de desordens temporomandibulares musculares
Other Titles: MMP2 polymorphysm is associated with muscular temporomandibular disorder absence
Authors: Cordeiro, Patrícia Cataldo de Felipe
metadata.dc.contributor.advisor: Reis, Priscila Ladeira Casado
Issue Date: 2018
Abstract: Desordens temporomandibulares (DTM) são caracterizadas por um conjunto de condições clínicas associadas a dor e/ou disfunção da musculatura mastigatória e articulações temporomandibulares (ATM), sendo as desordens musculares o grupo diagnóstico mais prevalente. As metaloproteinases de matriz (MMPs) são enzimas proteolíticas presentes na matriz extracelular e têm papel importante na adaptação do músculo esquelético. O objetivo do estudo foi avaliar a associação entre polimorfismos no gene MMP2 e a presença de desordens musculares. Aplicou-se o questionário Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TDM) para diagnóstico clínico das DTM. O grupo controle foi composto por 154 indivíduos, e dois outros grupos foram formados: DTM muscular (122) e DTM articular (n=49). O DNA genômico foi obtido a partir de amostras de saliva e seis polimorfismos de um só nucleotídeo no gene MMP2 (rs243865, rs2287074, rs243847, rs11639960, rs9923304, rs2285053) foram selecionados. Observou-se diferença significante entre a presença do genótipo C-T (rs243865) e a ausência de DTM muscular quando comparado ao grupo controle (p=0.05). Houve maior prevalência dos genótipos polimórficos CT + TT no grupo controle em relação ao grupo com DTM muscular. Confirmando esses resultados, o haplótipo TCCACC mostrou alta associação (p=0,01) com proteção a DTM musculares. Dessa forma, sugere-se que polimorfismos no gene MMP2 estejam relacionados com a ausência de DTM musculares
metadata.dc.description.abstractother: Temporomandibular disorders (TMD) are characterized by a set of clinical conditions associated with pain and/or dysfunction in the masticatory musculature and temporomandibular joints (TMJ), with muscle disorder being the most prevalent diagnostic group. Matrix metalloproteinases (MMPs) are proteolytic enzymes that play an important role in the adaptation of skeletal muscle. The aim of this study was to evaluate the association between polymorphisms in the MMP2 gene and the presence of muscular disorders. The Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) questionnaire was applied for clinical diagnosis of TMD. The control group consisted of 154 individuals, and two test groups were formed: muscular TMD (n=122) and joint TMD (n=49). Genomic DNA was obtained from saliva samples and 6 single nucleotide polymorphisms in the MMP2 gene (rs243865, rs2287074, rs243847, rs11639960, rs9923304, rs2285053) were selected. It was observed a tendency of association between the presence of the CT genotype (rs243865) and the absence of muscular TMD when compared to the control group (p=0.05). There was a significant prevalence of the polymorphic CT+TT (rs243865) genotypes in the control group (p=0.04) compared to the muscular TMD group (p=0,05). Confirming these results, TCCACC MMP2 haplotype showed higher association (p=0.01) with protection against muscular TMD. Thus, it was suggested that polymorphisms in the MMP2 gene are related to the protection to muscular TMD
URI: https://app.uff.br/riuff/handle/1/11511
Appears in Collections:PPGO - Teses e Dissertações

Files in This Item:
File Description SizeFormat 
Dissertação Patrícia Cataldo.pdf6.79 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons