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Title: Estudo de Resistência aos Antimicrobianos em Amostras de Pseudomonas Aeruginosa Isoladas em Hospitais da Cidade de Niteroi-RJ
Keywords: Medicina;  Patologia experimental;  Pseudomonas aeruginosa;  Resistência;  Carbapenase;  Resistência antimicrobiana;  Antimicrobial resistance;  Carbapenases;  Resistência microbiana a drogas
Issue Date: 1-Jan-2005
Publisher: Universidade Federal Fluminense
Abstract: A total of 162 P. aeruginosa strains was studied. They were isolated from patients attended in four hospitals located in Niterói city, Rio de Janeiro state, two of them supported by public health system: Hospital Azevedo Lima and Hospital Universitário Antônio Pedro, and the others from privative service: Hospital Santa Cruz and Casa de Saúde Santa Marta, between July 2002 and December 2003. The isolates were recovered from different clinical sources, including: urine (22.8%); secretions (52.5%); catheter tips (6.2%); blood specimens (8.6%); fluids (1.9%) and others (8%). All strains were susceptible to polimixin B. More than half of them showed resistance to cefotaxime (69.1%); ceftriaxone (65.5%); ciprofloxacin (54.9%); gentamicin (51.9%) and ticarcillin-clavulanic acid (50.6%), and in lower percentages to imipenem (35.8%); cefepime (33%); amikacin (32.1%); ceftazidime (30.9%); aztreonam (27.8%)and piperacillin-tazobactam (27.8%). Metallo-â-lactamase (M-âla) production was detected in 9 (5.6%) strains recovered from three of the four hospitals evaluated. The genetic diversity study was performed by chromosomal DNA fragmentation, after SpeI enzymatic treatment using Pulsed Field Gel Electrophoresis (PFGE). Among 19 strains selected from the study, 10 non M-âla producer multidrug-resistant strains showed a large variety of genetics profiles. However, the 9 M-âla producers were allocated in a single clonal group, the same genetic profile detected among P. aeruginosa M-âla producing strains, recovered in São Paulo city and Rio de Janeiro city, suggesting interhospital spread of strains at a local and regional level
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