Análise comparativa da acuidade visual em pacientes com oclusão de ramo de veia central da retina antes e após tratamento combinado de bevacizumabe intravítreo com fotocoagulação a laser

Abstract

Purpose: Compare the visual acuity (VA) in patients with branch retinal vein occlusion (BRVO), before and after been treated with a combination of intravitreal injection of bevacizumab followed by laser photocoagulation. Method: A retrospective analyses of patients with BRVO that underwent a treatment of intravitreal injection of bevacizumab (1,25mg/ 0,05ml) followed by laser photocoagulation on the affected area. Patients went through complete eye examination, including visual acuity measure with Snellen chart on the diagnostic visit and on the follow-ups. Uncompleted and miswritten charts ware excluded as well as charts of patients with others ocular affections that could interfere in visual acuity measure Results: 26 charts (11 male and 15 female) of patients with BRVO from the Ophthalmological Department of Santa Casa de Misericórdia Hospital during 2010 were analyzed. All patients underwent a 6 months follow-up. The average VA loss before diagnostics was 21.2 days (1-140). The average VA was 0.74 LogMAR (p<0,001) with improvement after 6 month of treatment to 0.32 LogMAR (p<0,001), representing a average gain of 0.42 LogMAR (p<0,001) or 19.4 ETDRS letters (p<0,001). Non parametric tests ware used to allow more generalization of the results avoiding normality assumption. The Wilcoxon was applied to verify de VA variation during de study. No eye or systemic complications ware observed during the study. Conclusions: Visual acuity gain occur comparing before and after treatment with bevacizumab intravitreal injection followed by laser photocoagulation. The stability of the gain combined with a absences of complications demonstrate de potential of combined intravitreal bevacizumab and laser photocoagulation in patients with BRVO.