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Title: Caracterização físico-química e avaliação in vitro e in vivo de grânulos de hidroxiapatita e hidroxiapatita/betatricálcio fostato
Keywords: Biomateriais;  Enxerto ósseo;  Hidroxiapatita;  b-Tricálcio Fosfato;  Biomaterials;  Bone graft;  Hydroxyapatite;  b-Tricalcium Phosphate;  MEDICINA;  CIÊNCIAS MÉDICAS;  Transplante ósseo;  Materiais biocompatíveis
Issue Date: 22-Dec-2012
Abstract: In last decades many efforts have been made to develop scaffolds to overcome the challenges of bone reconstruction. The calcium phosphate ceramics are very used because their similar chemical composition to the bone mineral compounds. The biphasic composites combine the biodegradation of the -TCP with the mechanical strength of the HA. The aim of this study was to describe the physicochemical properties and the biocompatibility of the HA and HA/-TCP (60/40), dense and porous, and evaluate their effect on the osteogenesis in the alveolar bone repair of rats. The biomaterials were implanted in the alveolar sockets immediately after dental extraction, and divided into 6 groups: group 1 (HA 100), group 2 (CPB 100), group 3 (HA 20), group 4 (CPB 20), Group 5 (HAp), Group 6 (CPBp) and the control group (without biomaterial). The granules (425-710 µm) with different pressures (100 e 20 MPa) applied during their processing, two groups of porous ceramics with an average of 355 mm in pore diameter. The materials were sintered under temperature of 1125 oC. The repair period was 7, 14 and 42 days. The results showed no physical and chemical structure altered of the materials. The citocompatibility multiparametric assay revealed the biocompatibility of the ceramics with the human primary mesenchymal cells. The in vivo results showed newly formed bone at 7 days in the groups of CPBs and more evident absorption areas. These scaffolds allowed the cell proliferation and infiltration, besides bone neoformation into the pores. In conclusion, the heat treatment and porogenic agent did not modify the structural properties and the biocompatibility of the ceramic materials. The inclusion of pores and -TCP increased the in vivo biodegradation and elected the materials as excellent and promising scaffolds in the bone reconstruction bioengineering
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